BRENDA - The Enzyme Database 
BRENDA is the most comprehensive expert updated relational database of molecular and metabolic information on more than 83,000 enzymes from 9,800 organisms according to the EC system of the IUBMB.

Data on enzyme function are extracted directly from the primary literature by scientists holding a degree in Biology or Chemistry. The database is developed at the Institute of Biochemistry at the University of Cologne. The curation is carried out by enzymeta GmbH.

BRENDA provides researchers in the domain of biochemistry and medicine a user friendly navigation system offering time saving access to a comprehensive summary of enzyme specific data from more than 46,000 publications.

The database includes biochemical and molecular information on classification, nomenclature, reaction, specificity, functional parameters, occurrence, enzyme structure, application, engineering, stability, disease, isolation, and preparation. The database also provides additional information on ligands, which function as natural or in vitro substrates/products, inhibitors, activating compounds, cofactors, bound metals, etc.

Now more than 500,000 enzyme-ligand relationships are stored with more than 46,000 different chemical compounds functioning as ligands and 34,500 structures of ligands from more than 56,600 publications.

BRENDA Ligand

BRENDA Ligand provides a search for all included synonyms of a given compound and thus facilitates finding all enzyme-ligand-related information. This is based on the generation of unique and chiral SMILES strings for ligand structures in the database.

BRENDA Ligand Substructure Search

BRENDA provides chemical substructure searches for most of the small molecules functioning as ligands, using a molecular editor.

Genome explorer

BRENDA Genome Explorer includes an up to date set of completely sequenced genomes (69 Archea, 1031 Bacteria, 1437 Eukaryota, 80 "viroides" and 1689 viruses). The primary source for the genome data is the EBI Genomes Server (www.ebi.ac.uk/genome). Source for eukaryotic genomes is the Ensembl database (www.ensembl.org). Additional annotations are obtained from the SwissProt/TrEMBL and UniRef databases (www.expasy.org), the COG database (www.ncbi.nlm.nih.gov/COG/), and the KEGG database (http://www.genome.jp).

The manually curated BRENDA database is effectively supplemented by the AMENDA add-on module through a fivefold increase in the enzyme-related references.

For more information, please contact  our sales team.